Isonicotinic Acid Hydrazide in the Treatment of Lupus Vulgaris

A diphosphopyridine nucleotidase and its protein inhibitor from Mycobacterium butyricum.

The diphosphopyridine nucleotidase exchange reaction, whereby isonicotinic acid hydrazide can replace nicotinamide in the DPN’ molecule, was demonstrated by Zatman el al. (1). Since this reaction provided a possible explanation for the growth inhibition of Mycobacteria by isonicotinic acid hydrazide, methods for measuring DPN in Mywbacteria were investigated. It was found that acetone powder ex...

Synthesis and structural studies of complexes of Cu, Co, Ni and Zn with isonicotinic acid hydrazide and isonicotinic acid (1-naphthylmethylene)hydrazide

Eight new complexes of Cu(II), Co(II), Ni(II) and Zn(II) with isonicotinic acid hydrazide (isoniazid, (INH)) and isonicotinic acid (1-naphthylmethylene)hydrazide (INNMH), having the formula of the type [M(INH)(ac)2] or [M(INNMH)(ac)2] (M = Co(II), Ni(II) and Zn(II)) and [Cu(INH)(ac)2]2, [Cu(INNMH)(ac)2]2, were synthesized and characterized. All complexes were characterized based on elemental an...

Charge Transfer Interactions between Isonicotinic Acid Hydrazide and Cupric Ions

The interaction of Cu2+ with isonicotinic acid hydrazide (INH) and some of its derivatives has been investigated by means of electron spin resonance, nuclear magnetic resonance, and optical absorption studies. It could be shown that an interaction exists between the metal ions and the hydrazine side chain in addition to the very weak interaction with the ring nitrogen. The results obtained indi...

The Treatment of Pulmonary Tuberculosis, T. B. Meningitis and T. B. Pericarditis with the Combination of Isonicotinic Acid Hydrazide and Streptomycin

Tuberculosis is one of the commonest invalidating diseases in this country. With the advent of the new antibiotic and chemotherapeutic remedies, the outlook is not as gloomy as .before. We have had the opportunity to study some cases treated with Unicozyde (Isonicotinic Acid Hydrazide 50 mgm. plus Vitamin C 50 mgm. per tablet) and Streptomycin with other established procedures like rest and min...

Isonicotinic Acid Hydrazide